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1-Intro


welcome to the

Mena lab

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1-Intro


welcome to the

Mena lab

Learn More

Laboratory of Neural Circuits

 

We are a multidisciplinary lab that studies how the brain selects information from the outside and orchestrates complex functions that are mediated by neuromodulators.

In particular, we aim to characterize the structural organization of neurons, to understand the signals that arise from the communication between neurons, and to integrate all these features in a behavioral framework.

 

 
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2-disease


2-disease


 
 

Mechanisms of disease

By understanding the rules of neural interactions, we will target the disordered communication between neurons and circuits that lies at the core of many brain diseases. 

 

 
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3-what_we_do


3-what_we_do


 

What we do

We use a series of techniques to study how neural circuits are composed and organized, how neuromodulatory neurons interact with other neural systems, and how the dysfunction of specific elements within a circuit lead to aberrant activity across systems. 

 

 
 

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Latest publications

Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits. Dautan D., Souza A.S., Huerta-Ocampo I., Valencia M., Assous M., Witten I.B., Deisseroth K., Tepper J.M., Bolam J.P., Gerdjikov T.V. and Mena-Segovia J. Nature Neuroscience (2016) AOP.

Structural and functional considerations of the cholinergic brainstem. Mena-Segovia J. J Neural Transm (Vienna) (2016) 123 (7): 731-6.

Extrinsic Sources of Cholinergic Innervation of the Striatal Complex: A Whole-Brain Mapping Analysis. Dautan D, Hacioğlu Bay H, Bolam JP, Gerdjikov TV and Mena-Segovia J. Frontiers in Neuroanatomy (2016) 10:1. 

Decoding brain state transitions in the pedunculopontine nucleus: cooperative phasic and tonic mechanisms. Petzold A., Valencia M., Pal B. and Mena-Segovia J. Frontiers in Neural Circuits (2015) 9:68. 

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Vacancies

PhD Studentships

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